





D-Panthenol (Pro-Vitamin B5)
Sold by weight (g or Kg) for formulation accuracy. Reference only: 250 g ≈ 240 mL (at 20°C).

Choose options






INGREDIENT OVERVIEW
D-Panthenol (Pro-Vitamin B5)
D-Panthenol (Pro-Vitamin B5) is a water-soluble cosmetic active used in formulations to support barrier function, improve hydration, and enhance overall formulation feel. It is widely used across serums, creams, and hair care products due to its compatibility and performance.
Our panthenol is supplied as a high-purity, cosmetic-grade liquid with a verified active content of 85.2% and low water content (0.13%). It is selected for consistent composition and reliable formulation performance.
QUALITY & SOURCING
- High active content (85.2% D-panthenol)
- Low water content (0.13%) for stability
- Balanced pH (~6.8 in solution)
- Consistent viscosity and clarity
- USP standard compliant
KEY SPECIFICATIONS
- Ingredient: D-Panthenol (Pro-Vitamin B5) - Cosmetic Grade
- INCI: Panthenol
- CAS: 81-13-0
- Solubility: Water soluble
- Typical use level:
- Leave-on: 1–5%
- Rinse-off: 1–2%
- Common in both skin and hair formulations
- Starter: 2-3% for most cosmetic formulations
FORMULATION NOTES
Processing notes
Add to the water phase with mixing until uniform. Suitable for cold-process and heated systems.
Compatibility notes
- Compatible with most cosmetic ingredients
- Works well with humectants and barrier-support actives
- Suitable for both skin and hair formulations
pH notes
Stable across typical cosmetic pH ranges (~4–7).
Formulation examples
Hydrating serum
- Panthenol: 2–5%
- Humectants (e.g. glycerin, propanediol): 3–6%
- Actives as required
- Preserved aqueous base to 100%
Supports hydration and barrier-focused formulations.
Lotion or cream (emulsion)
- Panthenol: 1–3% (water phase)
- Emollients and emulsifier system as required
- Preserved to finished formula
Improves skin feel and formulation balance.
Hair care system
- Panthenol: 1–3%
- Conditioning agents as required
- Surfactant or emulsion system
Supports conditioning and formulation performance
Troubleshooting
- Too sticky / heavy feel → reduce level or balance with lighter humectants
- Viscosity increase → adjust thickener system
- Cloudiness → review compatibility and system balance
COMPARISON & ALTERNATIVES
- Similar barrier support: niacinamideH
- ydration-focused: glycerin
- Soothing alternative: beta-glucan
- Premium alternative: ectoin
SENSORY PROFILE
Panthenol contributes a smooth, conditioned feel and can enhance formulation softness. At higher levels, it may slightly increase viscosity and leave a light film. Sensory outcome is formulation-dependent; bench testing is recommended.
STORAGE & HANDLING
- Store in a cool, dry place
- Keep container sealed
- Shelf life: 2 years when properly stored
- Refer to MSDS.
PRODUCT SAFETY
- Low irritation potential.
- Suitable for leave-on and rinse-off systems within recommended levels.
- Panthenol is considered non-hazardous when handled according to good industrial practice.
- Keep out of reach of children.
- Use appropriate PPE during handling and formulation.
- Refer to Safety Data Sheet (SDS) contained within documents tab.
DOCUMENTATION
- Cosmetic grade
- Assay: 85.2%
- Water content: 0.13%
- pH: ~6.8
- USP compliant
- COA and SDS available
Often paired with this ingredient
Explore a curated edit of key ingredients.
Learn more
Formulate with Confidence
Practical ingredient education and formulation guidance to help you choose, use and combine cosmetic ingredients with clarity.
Read All Articles
Article
What Does Panthenol Do in Skincare
Ingredient Knowledge
Ingredient Spotlight: Glycerin – Why It Remains a Formulation Essential
Ingredient Knowledge
Ingredient Spotlight: Squalane – Why It's One of Skincare's Most Loved Oils
Ingredient Knowledge
What Does Beta-Glucan Do in Skincare?
Ingredient Knowledge
Understanding Cosmetic Actives in Formulation
Ingredient Knowledge
Understanding Humectants in Cosmetic Formulations
Ingredient Knowledge
Why Formulators Use Ectoin
Ingredient Knowledge
Niacinamide for Barrier Support and Skin Balance
Formulation Systems
Understanding Core Ingredients in Cosmetic Formulation
Formulation Systems
Beginner Guide to Cosmetic Formulation: Building a Complete System
Beginner Formulation
What Does Pentylene Glycol Do in Skincare?
Beginner Formulation
How to Formulate a Hydrating Face Serum
Beginner Formulation
3 Ingredients Beginner Formulators Commonly Misuse - And How to Use Them Properly
Beginner Formulation
Why Glycerin Still Matters
Join the JNA Community
Get practical formulation tips, launches & ingredient updates.







